(https://www.pewtrusts.org/en/research-and-analysis/blogs/stateline/2018/05/10/abuse-of-opioid-alternative-gabapentin-is-on-the-rise), (https://medlineplus.gov/druginfo/meds/a694007.html), Visitation, mask requirements and COVID-19 information. The increased risk of suicidal thoughts or behavior was observed as early as 1 week after starting AEDs and persisted for the duration of treatment assessed. Avoid combinations; the risk of the interaction outweighs the benefit. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. Anxiolytic, sedative, and hypnotic agents have the potential to cause dependence and abuse. Quintero, Gabriel C. Review about gabapentin misuse, interact[]ns, and side effects. Journal of Experimental Pharmacology, February 9, 2017. Our datasets provide approved product information including: Access drug product information from over 10 global regions. While its common to co-prescribe opioids and gabapentin for nerve pain, the combination has anincreased riskfor sedation, respiratory depression, and abuse. Dilantin (phenytoin)." Drug Interaction Classification; These classifications are only a guideline. Do not discontinue abruptly as it may increase seizure frequency; gradually taper over a minimum of 1 week. . Call (888) 966-8152 Why call us? The following applies to the ingredients: Take other forms of gabapentin with or without food. (2001): Gericke CA, Ludolph AC "Chronic abuse of zolpidem." Gabapentin is not addictive, but this doesnt mean that gabapentin cant be abused. Drug interactions can also contribute to the cost of healthcare, as a serious drug interaction could result in injury, hospitalization, or rarely, death. Pregnancy categories A, B, C, D and X are being phased out. (1994): 1721-2. Doing so can release all of the drug at once, increasing the risk of side effects. Gabapentin is primarily eliminated unchanged by the kidney. Animal studies show risk and human studies are not yet available or neither animal nor human studies have been done. A total of 266 medications are known to interact with Serious Interactions. Elan Pharmaceuticals Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. (1994): 154-9. (2001): "Product Information. Yes, gabapentin does pass into breast milk. Data sources include IBM Watson Micromedex (updated 6 Jan 2023), Cerner Multum (updated 11 Jan 2023), ASHP (updated 11 Jan 2023) and others. Overdoses on gabapentin have been reported. If you have any concerns or questions, be sure to call your healthcare provider or pharmacist right away. Should I avoid certain foods while taking Gabapentin? (2005): "Product Information. Applicable conditions: Depression, Psychosis. Gabapentin is called a central nervous system (CNS)depressantbecause it slows down some of the functions and processes of the brain. Seek immediate medical attention if these symptoms develop: Products that interact with gabapentin include: Avoid drinking alcohol while taking gabapentin. Gabapentin, also known by its brand name Neurontin, is a medication that has been used in the United States since the early 1990s. Parke-Davis UCB Pharma Inc If you believe you are experiencing an interaction, contact a healthcare provider immediately. The branded gabapentin products Neurontin and Gralise are approved for partial seizures and PHN. Moderate Interactions. Buy Lyrica Tablets Online Pharmacy Sale You should point out to your medical professional any of the following clinical conditions you need to make certain your therapy goes as it needs to Lyrica Generic Name(s): pregabalin . Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. Use gabapentin with caution if benefits outweigh risks in pregnancy. If you did not receive a measuring device, please ask your pharmacist for a medication-measuring device. GlaxoSmithKline Eur Neuropsychopharmacol. She earned her Doctorate of Pharmacy from Rutgers University. Policy. Pooled analyses of 199 placebo-controlled clinical studies involving the use of 11 different AEDs across multiple indications in either monotherapy or adjunctive therapy for a median treatment duration of 12 weeks (up to a maximum of 24 weeks) showed that patients receiving AEDs had approximately twice the risk of suicidal thinking or behavior compared to patients receiving placebo. (Wait two hours after taking aluminum and magnesium-containing antacids before taking gabapentin.). This lesson describes some of its interactions with other drugs and . Moderately clinically significant. This is very important to remember when adding or removing gabapentin from a medication regimen that includes hydrocodone. Eye problems: unusual eye movements, double vision. It is safe to take gabapentin and other medications that have been prescribed or ordered by your doctor. Last reviewed by a Cleveland Clinic medical professional on 07/01/2021. May potentiate effects of other sedatives or ethanol when administered concomitantly. Pfizer U.S. Pharmaceuticals Group We do not endorse non-Cleveland Clinic products or services. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. The absence of an interaction does not necessarily mean no interactions exist. Learn more today! Gabapentin? Jonathan Strum graduated from the University of Nebraska Omaha with a Bachelor's in Communication in 2017 and has been writing professionally ever since. Lyricaand gabapentin are not typically recommended to be taken together because they both mimic the effects of the same chemical in the brain. These medications may cause some risk when taken together. restless legs syndrome, an extreme discomfort in the calf muscles when sitting or lying down, additional medication to treat partial seizures, diabetic complication causing injury to some body nerves. Bluish-colored or tinted skin, especially on lips, fingers or toes. Some of the most common side effects of gabapentin include drowsiness, weakness, dizziness, headache, and stomach upset. However, it is always important to check with your doctor or pharmacist about the specific OTC product. Mysoline (primidone)." Marinus Pharmaceuticals, Inc Dont drive, operate heavy machinery or do other dangerous activities after taking gabapentin until you know how it affects you. WebMD does not provide medical advice, diagnosis or treatment. Antiepileptic drugs (AEDs) have been associated with an increased risk of suicidal thoughts or behavior in patients taking these drugs for any indication. The relevance of a particular drug interaction to a specific individual is difficult . (2001): "Product Information. (2016): "Product Information. You and your healthcare provider will determine if you should take gabapentin during your pregnancy or change to a different medication. See additional information. Gabapentin belongs to a class of drugs known as anti-seizure drugs. Abbott Pharmaceutical Reported increased blood creatinine phosphokinase levels and muscle damage caused by inflammation. Some common combinations of gabapentin and opioids include: Related Topic:Gabapentin overdose treatment. Advertising on our site helps support our mission. These include antihistamines as well as products that contain magnesium or aluminum. Learn How Genetics Make Some Fans of Fear, Dr. Whyte's Book: Take Control of Your Cancer Risk, How Breast Cancer Changed My Life and Me, Health News and Information, Delivered to Your Inbox, AGENTS THAT MAY CAUSE RESPIRATORY DEPRESSION/SODIUM OXYBATE, GABAPENTIN/ALUMINUM; MAGNESIUM-CONTAINING COMPOUNDS, Focal Onset Seizures: Making Your Home Seizure-Safe, Understanding Focal Onset Seizures in Children, List Gabapentin side effects by likelihood and severity. [, Hendrich J, Van Minh AT, Heblich F, Nieto-Rostro M, Watschinger K, Striessnig J, Wratten J, Davies A, Dolphin AC: Pharmacological disruption of calcium channel trafficking by the alpha2delta ligand gabapentin. Avoid life-threatening adverse drug events & improve clinical decision support. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Major Potential Hazard, High plausibility. Drug and Food Interactions Close all Moderate Gabapentin + Food The following applies to the ingredients: Gabapentin Alcohol can increase the nervous system side effects of gabapentin such as dizziness, drowsiness, and difficulty concentrating. Zogenix, Inc Curr Opin Pharmacol. Gabapentin (brand names: Neurontin, Aclonium, Equipax, Gantin, Gabarone, Gralise, Neurostil, Progresse) is an anti-seizure and pain medication that is used with other medications to treat seizures and is also used to treat chronic pain, primarily nerve pain. Gabapentin. November 14, 2017. Highly clinically significant. (2018): "Product Information. Certain medicines for depression, such as amitriptyline, fluoxetine and sertraline. Always take gabapentin exactly as prescribed. GABA reduces the excitability of nerve cells (neurons) in the brain, which play a role in seizures and the transmission of pain signals. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. This document does not contain all possible interactions. Co-administration with food slightly alters pharmacokinetics, but not to a clinically significant extent. Select a condition to view a list of medication options. Should I avoid certain foods while taking Gabapentin? Also, do not split sustained-release tablets unless they have a score line and your doctor or pharmacist tells you to do so. Gabapentin is also used to manage a condition called postherpetic neuralgia, which is pain that occurs after shingles. However, if you have any questions regarding the medications that you are taking and the side effects of mixing those medications, talk to your doctor or pharmacist. Learn How Genetics Make Some Fans of Fear, Dr. Whyte's Book: Take Control of Your Cancer Risk, How Breast Cancer Changed My Life and Me, Health News and Information, Delivered to Your Inbox, AGENTS THAT MAY CAUSE RESPIRATORY DEPRESSION/SODIUM OXYBATE, GABAPENTIN/ALUMINUM; MAGNESIUM-CONTAINING COMPOUNDS, Focal Onset Seizures: Making Your Home Seizure-Safe, Understanding Focal Onset Seizures in Children, List Gabapentin side effects by likelihood and severity. The dosage is based on your medical condition and response to treatment. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, 6 Minutes of Exercise May Protect Brain From Alzheimer's, 'Disturbing' Rate of Adverse Events During Hospital Stays. If you are taking these medications together, talk to your doctor or pharmacist about the combination. Neurontin (gabapentin)." Its unknown if gabapentin can harm your unborn baby. (2009): "Product Information. InChI=1S/C9H17NO2/c10-7-9(6-8(11)12)4-2-1-3-5-9/h1-7,10H2,(H,11,12), Use our structured and evidence-based datasets to. Ambien (zolpidem)." Accessed August 4, 2019. Voltage-dependent calcium channel subunit alpha-2/delta-1, Voltage-dependent calcium channel subunit alpha-2/delta-2, Potassium voltage-gated channel subfamily KQT member 3, Potassium voltage-gated channel subfamily KQT member 5, Decreased Central Nervous System Disorganized Electrical Activity, Drugs causing inadvertant photosensitivity, Post Operative Nausea and Vomiting (PONV), Predicted MS/MS Spectrum - 10V, Positive (Annotated), Predicted MS/MS Spectrum - 20V, Positive (Annotated), Predicted MS/MS Spectrum - 40V, Positive (Annotated), Predicted MS/MS Spectrum - 10V, Negative (Annotated), Predicted MS/MS Spectrum - 20V, Negative (Annotated), Predicted MS/MS Spectrum - 40V, Negative (Annotated), LC-MS/MS Spectrum - LC-ESI-QTOF , negative, splash10-00di-0900000000-bccc9bd5f1637db7b6c7, splash10-00di-0900000000-67139ca9559173bf9859, splash10-0006-9000000000-bfe6527f738e4c67eb2b, LC-MS/MS Spectrum - LC-ESI-QTOF , positive, splash10-00di-0900000000-bb175ef297a289e1936b, splash10-0udr-0900000000-258d4493623d0ab7b415, splash10-0f79-0900000000-bc24764f394c6fee34fd, LC-MS/MS Spectrum - LC-ESI-ITFT , positive, splash10-0udi-0900000000-006ecd4a58af763b087f, splash10-00di-0900000000-012c52738f11970adb8d, splash10-00di-0900000000-8f0d390195aa406adb5d, splash10-0uk9-0900000000-72f8d5cb88eda76dab56, splash10-0udi-3900000000-b634b4e7144ec6ffdc83, splash10-0ktn-9800000000-20c4131179b228ab3440, splash10-00ke-9300000000-dd9d44ed4f16961ed075, splash10-00di-0900000000-f9a7deaa778e9d893ee8, splash10-00di-0900000000-4f85e6ac9fd91a3e3b81, splash10-0uk9-0900000000-d3a4c5658e343cf3cf8d, splash10-0udi-3900000000-712133d5b9eae1b27ffb, splash10-0ktn-9800000000-c652847259e0851b428e, splash10-00ke-9200000000-77e258cf26b045a7e46e, splash10-0udi-0900000000-bb0075e8b8166387ff3a, splash10-0uk9-0900000000-9e92acbd730e00943058, splash10-0pvs-9800000000-ba043efa192e3c526cab, splash10-0aou-9000000000-f44876af37d1698389cd, splash10-0udi-1900000000-8304d09827a02dd8f392, splash10-0005-9800000000-aa9f205e389c72aead8d, splash10-0udi-0900000000-eb3bc990b07a9471ea6e, splash10-0udi-0900000000-6514211d36ec828dafb5, splash10-0fk9-0900000000-fb527245013f4d56589f, Voltage-dependent N-type calcium channel (Protein Group), Voltage-dependent N-type calcium channel subunit alpha, Voltage-dependent N-type calcium channel subunit alpha-1B, Branched-chain-amino-acid aminotransferase, cytosolic, Large neutral amino acids transporter small subunit 1. Accessed August 4, 2019. Get useful, helpful and relevant health + wellness information. Epub 2005 Sep 1. Are pregnant, trying to become pregnant or are breastfeeding. In case of overdose, get medical help or contact a Poison Control Center immediately. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. Don't chew, break or crush. Gabapentin. (n.d.). If you forget to take a dose of gabapentin, take it as soon as you remember. Gabapentin may increase the central nervous system depressant (CNS depressant) activities of Aclidinium. Swallow tablets whole with a full glass of water. Gabapentin can interact with some over-the-counter (OTC) medications and supplements. Some of the drugs that can potentially interact with gabapentin include: Naproxen Studies suggest that naproxen (aleve) increases the amount of gabapentin absorbed in the body. 27 are major, 229 are moderate, and 10 are minor. Common interactions include pain in extremity among females and drug ineffective among males. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Common interactions include vomiting among females and nausea among males. Take Gralise tablets with your evening meal. Epub 2018 Jul 18. gabapentin, along with These medications may interact and cause very harmful effects. 2018 Oct;94(4):1155-1163. doi: 10.1124/mol.118.112953. In patients who have developed tolerance, overdosage can still produce respiratory depression and death. It should not be used in place of the advice of your physician or other qualified healthcare providers. Select a condition to view a list of medication options. Gabapentin is not a narcotic. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. The Recovery Village aims to improve the quality of life for people struggling with substance use or mental health disorder with fact-based content about the nature of behavioral health conditions, treatment options and their related outcomes. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Take gabapentin exactly as prescribed by your healthcare provider. Curr Top Med Chem. However, the individuals in these reports experienced symptoms after discontinuing higher-than-recommended doses of gabapentin and for uses for which the drug was not approved. We can help answer your questions and talk through any concerns. Gabapentin is commonly used with a cocktail of other anti-seizure drugs to control seizures. [, Dickens D, Webb SD, Antonyuk S, Giannoudis A, Owen A, Radisch S, Hasnain SS, Pirmohamed M: Transport of gabapentin by LAT1 (SLC7A5). 2013 Jun 1;85(11):1672-83. doi: 10.1016/j.bcp.2013.03.022. Also, never change your dose without talking to your provider first. Epub 2012 Jan 13. Biocodex USA You should avoid or limit the use of alcohol while being treated with gabapentin. Ztalmy (ganaxolone)." Common medications that may interact with gabapentin include: antacids, such as those containing aluminum and magnesium anti-anxiety medications, such as diazepam, lorazepam, and flunitrazepam antidepressants, such as amitriptyline, citalopram, fluoxetine, paroxetine antihistamines, such as chlorpheniramine, promethazine There were 4 suicides in AED-treated patients and none in placebo-treated patients, although the number is too small to establish any causal relationship. A small number of studies have reported misuse and abuse of gabapentin. Some of the mostcommon side effects of gabapentininclude drowsiness, weakness, dizziness, headache, and stomach upset. Of the total drug interactions, Gralise (gabapentin)." Vestal C. The Pew Charitable Trusts. The Neurological Institute is a leader in treating and researching the most complex neurological disorders and advancing innovations in neurology. . J Biol Chem. Epub 2013 Apr 6. This effect can occur when combining gabapentin and Benadryl (diphenhydramine) or gabapentin and Unisom (doxylamine). Generic Name Gabapentin DrugBank Accession Number DB00996 Background. AU TGA pregnancy category B3: Drugs which have been taken by only a limited number of pregnant women and women of childbearing age, without an increase in the frequency of malformation or other direct or indirect harmful effects on the human fetus having been observed. A licensed behavioral health or medical professional on The Recovery Village Editorial Team has analyzed and confirmed every statistic, study and medical claim on this page. Easily compare up to 40 drugs with our drug interaction checker. Klonopin (clonazepam)." The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. What Other Drugs Interact with Extended release formulation (Gralise) not interchangeable with immediate release. The following applies to the ingredients: Gabapentin Alcohol can increase the nervous system side effects of gabapentin such as dizziness, drowsiness, and difficulty concentrating. Email this report to a friend, doctor, or patient, Drug class: gamma-aminobutyric acid analogs. sanofi-aventis Minimally clinically significant. Gabapentin transfers into breast milk, consult with your physician. There are 266 drug interactions with gabapentin. Things to remember when you fill your prescription. If patients have symptoms of suicidal ideation or behavior, treatment should be discontinued. Gabapentin has no known severe interactions with any drugs. Side effects associated with abrupt discontinuation: Post marketing side effects of Gabapentin reported include: This document does not contain all possible side effects and others may occur. Accessed August 3, 2019. New Uses for Older Drugs: The Tales of A[]mide, and Gabapentin. Mayo Clinic Proceedings, June 2010. 1996-2023 RxList, Inc. All rights reserved. O 0, Cerner Multum, Inc. "Australian Product Information." Prac Pain Mgt, (https://www.practicalpainmanagement.com/treatments/pharmacological/non-opioids/special-report-abuse-potential-gabapentin-pregabalin). These medications may cause some risk when taken together. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. This drug crosses the human placenta. Drinking alcohol with gabapentin could increase sleepiness or dizziness. Cerebyx (fosphenytoin)." Gabapentin is used with other medications to prevent and control seizures. Epub 2008 Feb 25. Proc Natl Acad Sci U S A. Lundbeck Inc Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. Treatment Process Admissions Detox Rehab Moderately clinically significant. Dosage adjustments and titration should be made in accordance with product package labeling and individual patient response. 4 disease interactions, and 1 alcohol/food interaction. See "What Are Side Effects Associated with Using Gabapentin? An expert panel has deemed this drug is an acceptable choice for refractory restless leg syndrome during lactation. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. There is some evidence that gabapentin also acts on adenosine receptors15,12 and voltage-gated potassium channels,13 though the clinical relevance of its action at these sites is unclear. Some common combinations of gabapentin with other medications include: If you or someone you know is struggling with a substance use disorder orco-occurring mental healthissue, The Recovery Village can help. This survey is being conducted by the WebMD marketing sciences department. Ages 3-12 years: Risk of neuropsychiatric adverse events, including emotional lability, hostility, thought disorders, and hyperkinesia. "Pharmacokinetics of gabapentin in subjects with various degrees of renal function." Selected from data included with permission and copyrighted by First Databank, Inc. Its available as 100-, 300- or 400-milligram gelatin capsules (Neurontin or generic gabapentin). Drug Metab Pharmacokinet. Highly clinically significant. Does Gabapentin interact with other medications? Continuum (Minneap Minn). There are 4 disease interactions with gabapentin which include: Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. In rats, an increased incidence of hydroureter and/or hydronephrosis have been observed in offspring at all doses, the lowest dose being similar to the maximum recommended human dose on a mg/m2 basis. During the first 2 weeks of treatment, your doctor may gradually increase your dose so your body can adjust to the medication. RxList does not provide medical advice, diagnosis or treatment. 2006 Jan;102(1):182-7. Available for Android and iOS devices. Gabapentin is available as both a brand name product and a generic product (chemically the same, usually lower cost than the brand name product). Animal studies have revealed evidence of developmental toxicity (increased fetal skeletal and visceral abnormalities, and increased embryofetal mortality) when administered at doses similar to, or lower than expected clinical doses. Toxicology Data Network. It is also commonly combined with tramadol or NSAIDs such as carprofen or gapriprant for pain relief. It is also used to relieve nerve pain following shingles (a painful rash due to herpes zoster infection) in adults . Usually avoid combinations; use it only under special circumstances. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Swallow tablets whole with a full glass of water. -Women of childbearing potential should receive counseling on the risk of fetal abnormalities with use of antiepileptic drugs (AEDs) during pregnancy; AEDs should generally be continued during pregnancy utilizing monotherapy at the lowest effective dose as this has been shown to minimize risks of fetal abnormalities compared to combination AED therapy. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Medically Reviewed By Kathleen Oroho Linskey, PharmD. Use our structured and evidence-based datasets to unlock new insights and accelerate drug research. Please contact your doctor or pharmacist. Gabapentin can be removed by hemodialysis - this may be of benefit in some patients, such as those with impaired renal function.20, Multi-drug overdoses involving gabapentin, particularly in combination with other CNS depressants such as opioids, can result in coma and death - this possibility should be considered when managing overdosage.17. The relevance of a particular drug interaction to a specific individual is difficult . Semin Cell Dev Biol. Gabapentin is available in both branded and generic forms.